O-methoxybenzaldehyde
Structural Formula
Chinese name: o-methoxybenzaldehyde
Another name: o-methoxybenzaldehyde; 2-methoxybenzaldehyde; 2-anisaldehyde; o-anisaldehyde; o-methoxybenzaldehyde; salicaldehyde methyl ether; o-anisaldehyde; salicylaldehyde methyl ether
Molecular formula: C8H8O2
Molecular weight: 136.15
Numbering System
CAS Number: 135-02-4
EINECS: 205-171-7
HS code: 29124900
Technical Parameters
Appearance: colorless prismatic crystal
Purity: ≥98.0%
Melting point: 39°C
Boiling point: 238°C, 70-75°C/0.2kPa
Relative density: 1.1326 (20/4°C)
Refractive index: 1.5597
Flash point: 117°C
Solubility: soluble in alcohol, ether, benzene, insoluble in water
Production Method
From salicylaldehyde by methylation reaction with dimethyl sulfate. Mix 3kg of sodium hydroxide into a 30% aqueous solution, add 12.2kg of salicylaldehyde and 80L of water under stirring, and heat to boiling. Slowly add 12.9kg of dimethyl sulfate, keep the reaction solution refluxed for about 3h after adding, continue to reflux for 2-3h following Chemicalbook, cool the oil layer, wash with 5% sodium hydroxide solution, and then wash with water to pH 8, add Anhydrous potassium carbonate is dried. After filtering out the desiccant, distillation under reduced pressure, collecting the distillate at 120°C (2.0kPa), which is o-methoxybenzaldehyde. The methylation reaction can also be carried out in the solvent toluene, with a yield of 60%.
Purpose
Methoxybenzaldehyde is an intermediate in organic synthesis, used in the production of spices and medicines. The o-methoxybenformaldehyde can be used in production. O-Methoxybenzaldehyde can be used to produce the adrenergic drug Chuankening.
